The first thing you need to do is plug in the USB wire and make a connection to the ESC. After that, check the firmware version and probably upload firmware. Before ever trying to spin motors.
HOWEVER, this 5.3 version you have is relatively new software and not tested much yet. I can’t recommend more highly that you use an older version that’s known to work, while you’re trying to solve problems.
Version 5.2 in VESC Tool or variESC Tool would work for this.
If you use variESC Tool then a lot of the defaults are safer.