The biggest problem with moving up to a higher voltage will be a far fewer number of controllers you will be able to use, and those controllers might waste more energy as heat than the 60V controllers will. However the rest of the system besides the controller should run cooler overall. And the controller might not run hotter.
It’s very complicated really.
Your enclosure holding a 8x8 grid of cells is likely reason enough to use 16S.
If you’re doing a good order of operations, then this won’t be any problem at all: